Article
Modulation of Calcium Signaling on Demand to Decipher the Molecular Mechanisms of Primary Aldosteronism.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2025
Fedlaoui Bakhta, Cosentino Teresa, Al Sayed Zeina R, Alexandre Coelho Rita, Giscos-Douriez Isabelle, Faedda Nicolo, Fayad May, Hulot Jean-Sebastien, Magnus Christopher J, Sternson Scott M, Travers-Allard Simon, Baron Stephanie, Penton David, Fernandes-Rosa Fabio L, Zennaro Maria-Christina, Boulkroun Sheerazed
Abstract excerpt
BACKGROUND: Primary aldosteronism is the most common form of secondary hypertension. The most frequent genetic cause of aldosterone-producing adenomas is somatic mutations in the potassium channel KCNJ5. They affect the ion selectivity of the channel, with sodium influx leading to cell membrane depolarization and activation of calcium signaling, the major trigger for aldosterone biosynthesis. METHODS: To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.