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Article

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract.

Clinical and translational medicine - 1 Aug 2026

Yuan Ying, Zhang Li, Liao Jiongbo, Wang Bo, Lu Linghui, Chu Dongchen, Shi Yue, Liu Jiaqi, Zhang Feng, Tang Shuyan, Wang Chao

Abstract excerpt

BACKGROUND: Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) with gastric-type differentiation is a rare disorder with genetic predisposition. Pathogenic STK11 variants explain only a minority of reported cases, suggesting additional susceptibility genes. However, the genetic landscape of SMMN-FGT remains poorly characterised. METHODS: Whole-exome sequencing was performed on 19...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42605498
DOI: 10.1002/ctm2.70768
PMCID: PMC13478790

Genes

KDM5C
TP53
BRCA1
GCA
PIK3CA
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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