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Article

Genomic characterization of uterine adenomatoid tumors reveals recurrent alterations in KMT5A and KMT2C.

Clinical epigenetics - 17 May 2026

Kang Shufeng, Xu Fangfang, Tao Juan, Chen Guofang, Li Shuangdi

Abstract excerpt

BACKGROUND: Uterine adenomatoid tumors (UATs) are rare benign mesothelial neoplasms with poorly characterized molecular features. Comprehensive genomic profiling of UATs remains limited. METHODS: Targeted sequencing of 20 pathologically confirmed UATs was performed using a 641-gene panel. Immunohistochemical (IHC) analyses were conducted to assess protein expression patterns. Functional assays were performed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Histone-Lysine N-Methyltransferase

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Source

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Identifiers

PMID: 42144646
DOI: 10.1186/s13148-026-02161-6
PMCID: PMC13348700

Genes

KMT5A
KMT2C
TRAF7
CALB2
H2AX
KMT2A
ROS1
SDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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