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Article

Plasma proteins and irritable bowel syndrome: A proteome-wide Mendelian randomization study.

Medicine - 14 Aug 2026

Lei Yue, Liu Yiming

Abstract excerpt

Irritable bowel syndrome (IBS) is a complex disorder with unclear etiology and underlying mechanisms. This research aimed to identify possible plasma proteins linked to IBS using a proteome-wide Mendelian randomization (MR) analysis. We performed a bidirectional two-sample MR analysis to investigate the causal relationship between 4907 plasma proteins and IBS. Genetic data from 35,559 Icelanders and IBS...

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Identifiers

PMID: 42601749
DOI: 10.1097/MD.0000000000050229
PMCID: PMC13480754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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