Cell Senescence: A Challenge in Cartilage Engineering and Regeneration

Abstract excerpt

Cartilage defects, most commonly caused by aging and degenerative disease, have become the primary target of cartilage tissue engineering due to a lack of effective treatments and limited regenerative abilities. The limited success of autologous chondrocyte implantation necessitates the development of alternative cell sources. Adult mesenchymal stem cells (MSCs) with multiple lineage differentiation potentials...

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