Article
Genetic Landscape of Lynch Syndrome in a High-Risk Serbian Cohort: Predominance of MLH1 Variants and Implications for Risk-Based Testing.
International journal of molecular sciences - 25 Jul 2026
Djordjic Crnogorac Marija, Karadzic Valentina, Cato Teodora, Cavic Milena, Nikolic Neda, Spasic Jelena, Djordjevic Fedja, Jokic Vladimir, Kocic Milan, Djurasinovic Miroslav, Kukic Biljana, Nikolic Srdjan, Ristic Marija, Milovic Marijana, Krivokuca Ana
Abstract excerpt
Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, caused by germline pathogenic or likely pathogenic variants (PV/LPV) in mismatch repair (MMR) genes. Data on the spectrum of LS-associated variants in Slavic populations, including Serbia, remain limited. Given the high burden of CRC and endometrial cancer and the limited implementation of hereditary CRC screening, characterizing...
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