Article
Mapping the Prevalence of Lynch Syndrome in the Ceará-Northeast of Brazil.
Clinical genetics - 1 Apr 2026
Dos Santos Luciano Maria Claudia, de Barros Silva Paulo Goberlanio, de Sant'Ana Rosane Oliveira, de Albuquerque Clarissa Gondim Picanço, Oliveira Francisca Fernanda Barbosa, da Silveira Bitencourt Flavio, de Lima Silva Fernandes Isabelle Joyce, Moura José Fernando Bastos, Bezerra Maria Júlia Barbosa
Abstract excerpt
Lynch syndrome (LS) is an autosomal dominant hereditary disorder that increases the risk of various cancers, especially colorectal (CRC) and endometrial cancer (EC). It results from pathogenic variants in mismatch repair (MMR) genes-primarily MLH1, MSH2, MSH6, and PMS2. Population-specific variant frequencies emphasize the need for localized genetic studies. Methods This study investigated LS prevalence in Ceará,...
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