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Article

Targeted sequencing reveals a distinct genetic alteration landscape in oral multiple primary squamous cell carcinomas.

Archives of oral biology - 1 Nov 2026

Zhou Xuan, Zhang Jianyun, Zhang Heyu, Li Tiejun

Abstract excerpt

OBJECTIVE: Oral multiple primary cancers (MPCs) are associated with poor clinical outcomes, yet their genomic characteristics remain insufficiently understood. DESIGN: Fifty-four formalin-fixed paraffin-embedded (FFPE) tumor samples from 30 patients with oral MPCs were analyzed using high-depth targeted sequencing of a customized 14-gene panel derived from prior whole-exome sequencing data. Detected alterations...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Squamous Cell
Female
Mutation
Mouth Neoplasms
Male
A Kinase Anchor Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Paraffin Embedding

Aged

Middle Aged

Neoplasms, Multiple Primary

DNA Mutational Analysis

Source

Identifiers

PMID: 42585843
DOI: 10.1016/j.archoralbio.2026.106716

Genes

AKAP13
TP53
DNAH8
GLI2
JMJD1C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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