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Article

Whole-exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets.

The Journal of pathology - 1 Mar 2018

Lyu Jiong, Song Zhijian, Chen Jianhua, Shepard Matthew J, Song Hao, Ren Guoxin, Li Zhiqiang, Guo Wei, Zhuang Zhengping, Shi Yongyong

Abstract excerpt

Oral mucosal melanoma (OMM) is a rare and aggressive subtype of melanoma with little known about its pathogenesis or carcinogenesis. We therefore performed whole-exome sequencing (WES) on 19 matched OMM tumor/normal pairs in order to gain insight into potential genetic drivers of tumor formation. For the first time, we describe the comprehensive mutational profile of OMM. Our data suggest that the genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29230811
DOI: 10.1002/path.5017

Genes

KIT
CDK4
TERT
DMXL2
POLE
PTPRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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