Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.

Oncotarget - 13 Dec 2016

Arjumand Wani, Merry Cole D, Wang Chen, Saba Elias, McIntyre John B, Fang Shujuan, Kornaga Elizabeth, Ghatage Prafull, Doll Corinne M, Lees-Miller Susan P

Abstract excerpt

The phosphatidylinositol-3 kinase (PI3K)/Akt/mTOR signaling pathway is activated in many human cancers. Previously, we reported that patients with early stage cervical cancer whose tumours harbour PIK3CA exon 9 or 20 mutations have worse overall survival in response to treatment with radiation and cisplatin than patients with wild-type PIK3CA. The purpose of this study was to determine whether PIK3CA-E545K...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Chemoradiotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Class I Phosphatidylinositol 3-Kinases

Share to Dose-Response Relationship, Radiation

Share to Neoplasm Invasiveness

Share to Proto-Oncogene Proteins c-akt

Share to Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27489350
DOI: 10.18632/oncotarget.10955
PMCID: PMC5347702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.PMID 27489350Read ↗

Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling.Semantic proximity Read ↗

Prognostic significance of PIK3CA mutation in stage IIB to IVA cervical cancers treated by concurrent chemoradiotherapy with weekly cisplatin.Semantic proximity Read ↗

High incidence of PI3K pathway gene mutations in South Indian cervical cancers.Semantic proximity Read ↗

Genomic analysis of cervical carcinoma identifies Alpelisib as a therapeutic option for PIK3CA-mutant cervical carcinoma via the PI3K/AKT pathway.Semantic proximity Read ↗

Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.Semantic proximity Read ↗

Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications.Semantic proximity Read ↗

Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example.Semantic proximity Read ↗

Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.Semantic proximity Read ↗

PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancer.Semantic proximity Read ↗

PIK3CA mutation analysis in Chinese patients with surgically resected cervical cancer.Semantic proximity Read ↗

Genetic variations in the PI3K/AKT pathway predict platinum-based neoadjuvant chemotherapeutic sensitivity in squamous cervical cancer.Semantic proximity Read ↗

Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole‐imidazole polyamide in cervical cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.