Article
"THE SAB GAP": Incomplete HLA allele representation in Single Antigen Bead assays and its implications for surrogate epitope-level representation in an Indian transplant cohort.
Human immunology - 1 Oct 2026
Chowdhry Mohit, Yadav Ayushi, Karthikeyan Jayagowri
Abstract excerpt
BACKGROUND: Single Antigen Bead (SAB) assays are widely used for anti-HLA antibodies detection and virtual crossmatch. Their interpretation assumes that omission of specific HLA alleles can be adequately compensated through representation of shared epitopes on related alleles included within the panel. METHODS: This study retrospectively examined 535 Indian donor-recipient pairs to pinpoint HLA alleles missing...
Read the complete abstract on PubMedTopics
- Humans
- Histocompatibility Testing
- Alleles
- HLA Antigens
- Epitopes
- India