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Article

Unrepresented human leucocyte antigen alleles in single-antigen bead assays: A single-centre cohort study.

International journal of immunogenetics - 1 Dec 2023

Ho Quan Yao, Phang Chew Yen, Liew Ian Tatt, Lai May Ling, Tien Carolyn Shan-Yeu, Thangaraju Sobhana, Chan Marieta, Kee Terence

Abstract excerpt

Human leucocyte antigen (HLA) alleles may generate antibodies that are undetectable by routine single-antigen beads (SABs) assays if their unique epitopes are unrepresented. We aimed to describe the prevalence and explore the potential impact of unrepresented HLA alleles in standard SAB kits in our cohort. All individuals who had undergone two-field HLA typing (HLA-A/B/C/DRB1/DQA1/-DQB1/-DPA1/-DPB1) from February...

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PMID: 37776087
DOI: 10.1111/iji.12639

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