Population-agnostic real-time molecular mismatch estimation using rSSO-defined HLA allele strings: minimal impact of allelic discordance with NGS.

Abstract excerpt

Background: Molecular HLA mismatch at the epitope level is strongly associated with donor-specific antibody formation, antibody-mediated rejection, and graft failure after transplantation. Accurate molecular mismatch assessment requires high-resolution HLA typing; however, in clinical practice-particularly in deceased donor transplantation-typing is often performed at low or intermediate resolution....

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