Child-to-adult body size trajectories and risk of rheumatoid arthritis: the mediating role of metabolic unhealthiness, low-grade inflammation, and the modifying effect of genetic susceptibility.

doi:10.1016/j.jaut.2026.103612

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Article

Child-to-adult body size trajectories and risk of rheumatoid arthritis: the mediating role of metabolic unhealthiness, low-grade inflammation, and the modifying effect of genetic susceptibility.

Journal of autoimmunity - 1 Sept 2026

Wan Xing-Yu, Huang Wei, Wang Yi-Xu, Hu Yi-Han, Jing Shi-Hao, Zhang Chao, Leng Rui-Xue, Gu Long, Wang Qi, Di Dong-Sheng

Abstract excerpt

OBJECTIVE: To investigate the association between body size changes from childhood to adulthood and rheumatoid arthritis (RA), considering the roles of metabolic unhealthiness, low-grade inflammation, and genetic susceptibility. METHODS: Data from the UK Biobank on 482,264 RA-free participants were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. Cox...

Read the complete abstract on PubMed

Topics

Humans
Arthritis, Rheumatoid
Genetic Predisposition to Disease
Body Size
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Inflammation

Male

Child

Risk Factors

Middle Aged

Body Mass Index

Adolescent

United Kingdom

Source

Open in PubMed

Identifiers

PMID: 42561459
DOI: 10.1016/j.jaut.2026.103612

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