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A mini review of genome-predicted β-lactam susceptibility in Streptococcus pneumoniae: from PBP profiles to potential clinical interpretation

22 Jul 2026

Abstract excerpt

β-Lactams remain central to the treatment of pneumococcal infections, and whole-genome sequencing increasingly enables pneumococcal β-lactam susceptibility to be inferred from the combined transpeptidase-domain sequences of PBP1a, PBP2b, and PBP2x. PBP-profile lookup, statistical models, and integrated genomic pipelines can predict drug-specific minimum inhibitory concentrations with high overall agreement with...

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PMID: 42558410
DOI: 10.3389/fcimb.2026.1901030

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