Article
Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences.
BMC genomics - 15 Aug 2017
Li Yuan, Metcalf Benjamin J, Chochua Sopio, Li Zhongya, Gertz Robert E, Walker Hollis, Hawkins Paulina A, Tran Theresa, McGee Lesley, Beall Bernard W
Abstract excerpt
BACKGROUND: Genomic sequence-based deduction of antibiotic minimum inhibitory concentration (MIC) has great potential to enhance the speed and sensitivity of antimicrobial susceptibility testing. We previously developed a penicillin-binding protein (PBP) typing system and two methods (Random Forest (RF) and Mode MIC (MM)) that accurately predicted β-lactam MICs for pneumococcal isolates carrying a characterized...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.