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Article

The SARS-CoV-2 S2'-helix compared to stem helix confers higher genetic barrier to antibody resistance.

PLoS pathogens - 1 Aug 2026

Wang Xuanjia, Qiao Shitong, Bao Zhiheng, Bai Jiaxiu, Yi Chunyan, Ding Qiang, Sun Xiaoyu

Abstract excerpt

Understanding the potential for resistance to antibodies targeting conserved epitopes on the coronavirus spike protein is essential for developing broad-spectrum antivirals. The S2'-helix and stem helix represent two key conserved epitopes across multiple coronaviruses, with the S2'-helix being broadly conserved throughout the coronavirus subfamily and the stem helix primarily conserved among betacoronaviruses....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42550874
DOI: 10.1371/journal.ppat.1014497
PMCID: PMC13466045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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