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Beyond culturability: VBNC-like and differentially culturable Mycobacterium tuberculosis challenge growth-based interpretations of bacterial viability.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Niu Jing, Zhang Peng, Wei Zihan, Zou Yuanwu, Wang Zhuo

Abstract excerpt

Culturability remains the predominant method for assessing bacterial viability in tuberculosis research and clinical practice. However, growth-based detection provides only a limited and context-dependent dimension of Mycobacterium tuberculosis (MTB) survival. MTB populations may evade recovery by standard culture while retaining molecular, metabolic, or functional features inconsistent with irreversible cellular...

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Identifiers

PMID: 42548556
DOI: 10.3389/fcimb.2026.1896879
PMCID: PMC13429380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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