Article
Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.
PLoS pathogens - 1 Jul 2019
Hommel Benjamin, Sturny-Leclère Aude, Volant Stevenn, Veluppillai Nathanaël, Duchateau Magalie, Yu Chen-Hsin, Hourdel Véronique, Varet Hugo, Matondo Mariette, Perfect John R, Casadevall Arturo, Dromer Françoise, Alanio Alexandre
Abstract excerpt
Metabolically quiescent pathogens can persist in a viable non-replicating state for months or even years. For certain infectious diseases, such as tuberculosis, cryptococcosis, histoplasmosis, latent infection is a corollary of this dormant state, which has the risk for reactivation and clinical disease. During murine cryptococcosis and macrophage uptake, stress and host immunity induce Cryptococcus neoformans...
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