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Article

Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.

PLoS pathogens - 1 Jul 2019

Hommel Benjamin, Sturny-Leclère Aude, Volant Stevenn, Veluppillai Nathanaël, Duchateau Magalie, Yu Chen-Hsin, Hourdel Véronique, Varet Hugo, Matondo Mariette, Perfect John R, Casadevall Arturo, Dromer Françoise, Alanio Alexandre

Abstract excerpt

Metabolically quiescent pathogens can persist in a viable non-replicating state for months or even years. For certain infectious diseases, such as tuberculosis, cryptococcosis, histoplasmosis, latent infection is a corollary of this dormant state, which has the risk for reactivation and clinical disease. During murine cryptococcosis and macrophage uptake, stress and host immunity induce Cryptococcus neoformans...

Topics

Animals
Cryptococcosis
Cryptococcus neoformans
Culture Media
Fatty Acids
Fungal Proteins
Humans
Mice
Microbial Viability
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxygen

Pantothenic Acid

Phenotype

Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 31356623
DOI: 10.1371/journal.ppat.1007945
PMCID: PMC6687208

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