Vascular engineering using human embryonic stem cells

Abstract excerpt

Engineering vascularized tissue constructs remains a major problem in regenerative medicine. The formation of such a microvasculature--like the vasculogenesis in early embryogenesis that it closely resembles--is guided by biochemical and biophysical cues, such as growth factors, extracellular matrix proteins, hypoxia, and hydrodynamic shear. As they undergo spontaneous and directed vascular differentiation, human...