Article
Functional vascular endothelium derived from human induced pluripotent stem cells.
Stem cell reports - 1 Jan 2013
Adams William J, Zhang Yuzhi, Cloutier Jennifer, Kuchimanchi Pranati, Newton Gail, Sehrawat Seema, Aird William C, Mayadas Tanya N, Luscinskas Francis W, García-Cardeña Guillermo
Abstract excerpt
Vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. Human genotype-phenotype studies of endothelium are limited by the unavailability of patient-specific endothelial cells. To establish a cellular platform for studying endothelial biology, we have generated...
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