Article
Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant Phenotypes.
Stem cell reviews and reports - 1 Jan 2026
Nguyen Vi, Harper Anna, Azuero Mackenzie, Castellanos Isabella, He Siwuxie, Hochman Marcelo L, Wenceslau Camilla F, Chen Dong-Bao, Jegga Anil G, Wang Yunguan, Fan Daping, Nelson J Stuart, Tan Wenbin
Abstract excerpt
Capillary malformation (CM) is a congenital vascular anomaly that affects the skin, mucosa, eye, and brain. A major obstacle to mechanistic and drug screening studies for CM has been the lack of preclinical models. In this study, we established vascular organoids (VOs) generated through the self-assembly of vascular lineages of endothelial cells and smooth muscle cells differentiated from CM-induced pluripotent...
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