Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.

EBioMedicine - 1 Sept 2017

White Michelle M, Geraghty Patrick, Hayes Elaine, Cox Stephen, Leitch William, Alfawaz Bader, Lavelle Gillian M, McElvaney Oliver J, Flannery Ryan, Keenan Joanne, Meleady Paula, Henry Michael, Clynes Martin, Gunaratnam Cedric, McElvaney Noel G, Reeves Emer P

Abstract excerpt

BACKGROUND: Identification of mechanisms promoting neutrophil trafficking to the lungs of patients with cystic fibrosis (CF) is a challenge for next generation therapeutics. Cholesterol, a structural component of neutrophil plasma membranes influences cell adhesion, a key step in transmigration. The effect of chronic inflammation on neutrophil membrane cholesterol content in patients with CF (PWCF) remains...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calpain
Share to Caveolin 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to HL-60 Cells

Share to Inflammation Mediators

Share to Membrane Microdomains

Share to Neutrophils

Share to Respiratory Function Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 28835336
DOI: 10.1016/j.ebiom.2017.08.013
PMCID: PMC5605378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.PMID 28835336Read ↗

CFTR modulators exert subset-specific phenotype remodeling on circulating neutrophils in cystic fibrosis.Semantic proximity Read ↗

CFTR mutation leads to intrinsic dysfunction in neutrophils from people with Cystic FibrosisSemantic proximity Read ↗

The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective CellSemantic proximity Read ↗

Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosisSemantic proximity Read ↗

Protein Processing and Inflammatory Signaling in Cystic Fibrosis: Challenges and Therapeutic StrategiesSemantic proximity Read ↗

Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype.Semantic proximity Read ↗

Effects of ivacaftor on systemic inflammation and the plasma proteome in people with CF and G551D.Semantic proximity Read ↗

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.Semantic proximity Read ↗

Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations.Semantic proximity Read ↗

Cystic Fibrosis Lung Immunity: The Role of the MacrophageSemantic proximity Read ↗

Immune Responses in Cystic FibrosisSemantic proximity Read ↗

Impact of CFTR Modulators on the Impaired Function of Phagocytes in Cystic Fibrosis Lung Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.