Article
Leber hereditary optic neuropathy-new insights and old challenges.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Sept 2021
Sundaramurthy Srilekha, SelvaKumar Ambika, Ching Jared, Dharani Vidhya, Sarangapani Sripriya, Yu-Wai-Man Patrick
Abstract excerpt
Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) disorder with the majority of patients harboring one of three primary mtDNA point mutations, namely, m.3460G>A (MTND1), m.11778G>A (MTND4), and m.14484T>C (MTND6). LHON is characterized by bilateral subacute loss of vision due to the preferential loss of retinal ganglion cells (RGCs) within the inner retina, resulting in...
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