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Leber's hereditary optic neuropathy: Update on the novel genes and therapeutic options.

Journal of the Chinese Medical Association : JCMA - 1 Jan 2024

Hu Jui-Lin, Hsu Chih-Chien, Hsiao Yu-Jer, Lin Yi-Ying, Lai Wei-Yi, Liu Yu-Hao, Wang Chia-Lin, Ko Yu-Ling, Tsai Ming-Long, Tseng Huan-Chin, Chien Yueh, Yang Yi-Ping

Abstract excerpt

A maternal inheritance disorder called Leber's hereditary optic neuropathy (LHON) is the most common primary mitochondrial deoxyribonucleic acid (DNA) disorder. In most studies, there are more male patients than female patients, which contradicts the usual pattern in mitochondrial hereditary diseases. This suggests that nuclear DNA (nDNA) may influence the degeneration of retinal ganglion cells (RGCs) in LHON....

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PMID: 38016117
DOI: 10.1097/JCMA.0000000000001031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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