Article
CYP2C19 c.681G>A Is not in Complete Linkage Disequilibrium With c.332-23A>G: Implications for Pharmacogenetic Testing.
Clinical and translational science - 1 Aug 2026
Turner Amy J, Boone Erin C, Haidar Cyrine E, Yang Wenjian, Derezinski Ashley D, Haddad Andrew, Empey Philip E, Broeckel Ulrich, Gaedigk Andrea
Abstract excerpt
CYP2C19 plays an important role in the metabolism of many medications, including the antiplatelet agent clopidogrel, the antifungal agent voriconazole, selective serotonin reuptake inhibitors, select tricyclic antidepressants, and proton pump inhibitors. The Clinical Pharmacogenetics Implementation Consortium has published several guidelines emphasizing the importance of CYP2C19 genotype-guided therapy to...
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