Article
A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect.
Journal of translational medicine - 26 Jul 2013
Younesi Erfan, Hofmann-Apitius Martin
Abstract excerpt
BACKGROUND: While the majority of studies have focused on the association between sex hormones and dementia, emerging evidence supports the role of other hormone signals in increasing dementia risk. However, due to the lack of an integrated view on mechanistic interactions of hormone signaling pathways associated with dementia, molecular mechanisms through which hormones contribute to the increased risk of...
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