Heterozygous BRCA1 SNPs in the Central Functional Region are Associated With Increased Sensitivity to PARP Inhibition in Breast Cancer Cells.

Abstract excerpt

INTRODUCTION: Poly (ADP-ribose) polymerase (PARP) inhibitors demonstrate efficacy in breast cancer patients harboring pathogenic BRCA1/2 mutations. However, certain BRCA1 single nucleotide polymorphisms may alter protein function without complete loss of activity. This study investigates whether specific heterozygous BRCA1 single nucleotide polymorphisms within the central functional region of BRCA1 affect...

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• BRCA1 Protein
• Breast Neoplasms
• Cell Survival
• Drug Resistance, Neoplasm
• Gene Expression Regulation, Neoplastic