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Article

Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors.

Molecular diagnosis & therapy - 1 Apr 2020

Chevalier Louise-Marie, Billaud Amandine, Fronteau Sabrina, Dauvé Jonathan, Patsouris Anne, Verriele Véronique, Morel Alain

Abstract excerpt

BACKGROUND: The identification of pretherapeutic somatic BRCA variants can have considerable clinical impact given that they affect response to the new poly (ADP-ribose) polymerase (PARP)-targeted therapy. One major issue with this type of testing is the identification of splicing variants of uncertain significance (VUS) on degraded somatic messenger RNA. It is therefore important to be able to quickly...

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Alternative Splicing
BRCA1 Protein
High-Throughput Nucleotide Sequencing
Ovarian Neoplasms
Poly(ADP-ribose) Polymerase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

Reverse Transcriptase Polymerase Chain Reaction

Tissue Fixation

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PMID: 32124385
DOI: 10.1007/s40291-020-00452-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors.PMID 32124385Read ↗

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