Article

Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with Veliparib

2020-03-09

Abstract excerpt

Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors have been suggested to act by either catalytic inhibition or by PARP localization in chromatin. In this study, we treat human HCC1937 BRCA1 mutant and isogenic BRCA1 -complemented cells for three weeks with veliparib, a PARP inhibitor. We sh...

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Literature Corpus work: 8db9c6c1-a767-5249-9f01-4d2195f2ff94
DOI: 10.1101/2020.03.08.982785

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Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with VeliparibDOI 10.1101/2020.03.08.982785Read

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