[Causal associations between immune cell phenotypes and Ménière's disease: a bidirectional two-sample Mendelian randomization study and validation in mice].

Abstract excerpt

OBJECTIVES: To explore the causal relationship between 731 immune cell phenotypes and Ménière's disease (MD) using Mendelian randomization (MR) analysis and experimental validation in mice. METHODS: Based on GWAS data and with immune cell phenotypes and MD as the exposure and outcome variables respectively, we conducted MR analysis using inverse variance weighting (IVW) supplemented by MR-Egger and weighted...

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