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Mendelian randomization and genetic analyses reveal causal roles of immune cells and inflammatory proteins in keratoconus

16 Jul 2025

Abstract excerpt

Immunity and inflammation are implicated in the progression of keratoconus (KC), but the causal relationships between inflammatory immune phenotypes and the disease remain unclear. We conducted a comprehensive Mendelian randomization (MR) analysis using GWAS data to investigate the causal effects of inflammatory and immune factors on KC. Multiple sensitivity analyses were performed to validate our findings, with...

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Corneal surgery and disorders
Corneal Surgery and Treatments
Ocular Surface and Contact Lens

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40670523
DOI: 10.1038/s41598-025-10759-8

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