Complex causal association between immunophenotypes and adenomyosis: Univariable, bidirectional, and multivariable Mendelian randomization.

Abstract excerpt

This study aimed to explore the causal link between immunophenotypes and adenomyosis using Mendelian randomization (MR). We conducted a bidirectional MR analysis on 731 immunophenotypes, employing inverse-variance weighted (IVW) as the primary method, supplemented by MR-Egger, weighted mode, and weighted median analyses. Sensitivity analyses were performed to ensure result robustness. Multivariable MR was also...

Topics

• Humans
• Adenomyosis
• Female
• Mendelian Randomization Analysis
• Immunophenotyping
• Risk Factors