IL10 promoter variants in neurocysticercosis: Family-based susceptibility and exploratory genotype-phenotype analyses in Mexican case-parent trios.

Abstract excerpt

Given the central role of neuroinflammation in neurocysticercosis (NCC), IL10 promoter variation may influence susceptibility and disease expression. We analyzed rs1800896 (-1082 A > G), rs1800871 (-819C > T), and rs1800872 (-592C > A), together with reconstructed haplotypes/diplotypes, in 92 Mexican case-parent trios. Susceptibility was assessed by exact transmission disequilibrium testing, and exploratory...