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Article

Hyperfusogenic Mutations Destabilize the Postfusion Six-Helix Bundle of the Measles Virus Fusion Glycoprotein.

Biochemistry - 4 Aug 2026

Vithanage Nisansala, Outlaw Victor K

Abstract excerpt

Fusion of the host membrane and viral envelope by class I viral fusion proteins is driven by the assembly of a postfusion six-helix bundle formed through antiparallel interactions between N-terminal (HR1) and C-terminal (HR2) heptad-repeat regions. Although mutations in these regions of the measles virus (MeV) fusion (F) glycoprotein are known to promote neuropathogenic and hyperfusogenic phenotypes, their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42485314
DOI: 10.1021/acs.biochem.6c00182
PMCID: PMC13445589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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