Article
Splenectomy enhances the Ly6Clow phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
International immunopharmacology - 1 Sept 2020
Zheng Zhongqiang, Wang Huan, Li Liang, Zhang Shaoying, Zhang Chunyan, Zhang Hailong, Ji Fanpu, Liu Xi, Zhu Kai, Kong Guangyao, Li Zongfang
Abstract excerpt
BACKGROUND AND AIM: Splenectomy has been reported to attenuate liver fibrosis. In addition, phenotype transitions of infiltrating macrophages, including Ly6Chigh and Ly6Clow, play an essential role in the liver fibrosis. However, whether the spleen can regulate the phenotype switch of macrophages and the underlying mechanism still remain unclear. METHODS: Chronic liver fibrosis in mice was induced by...
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