Golgi-Pattern PDGFRA Immunoreactivity Correlates With PDGFRA Mutation Status in Gastric Epithelioid and Mixed-Type Gastrointestinal Stromal Tumors.

doi:10.1097/PAI.0000000000001342

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Article

Golgi-Pattern PDGFRA Immunoreactivity Correlates With PDGFRA Mutation Status in Gastric Epithelioid and Mixed-Type Gastrointestinal Stromal Tumors.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2026

Ali Rola H, Alwazan Maram, George Smiley, Alsaber Ahmad R, Alkandari Mohammad

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) with PDGFRA mutations represent a distinct subset with characteristic clinicopathological features and important therapeutic implications. The diagnostic performance of PDGFRA immunohistochemistry (IHC) as a phenotypic correlate of PDGFRA mutation status requires further evaluation. This study aimed to assess the diagnostic performance and reproducibility of PDGFRA IHC...

Read the complete abstract on PubMed

Topics

Humans
Gastrointestinal Stromal Tumors
Receptor, Platelet-Derived Growth Factor alpha
Mutation
Immunohistochemistry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Golgi Apparatus

Male

Anoctamin-1

Stomach Neoplasms

Proto-Oncogene Proteins c-kit

Gastrointestinal Neoplasms

Biomarkers, Tumor

Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42482629
DOI: 10.1097/PAI.0000000000001342
PMCID: PMC13533463

Genes

PDGFRA
KIT
CD34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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