Article
Value of epithelioid morphology and PDGFRA immunostaining pattern for prediction of PDGFRA mutated genotype in gastrointestinal stromal tumors (GISTs).
International journal of clinical and experimental pathology - 1 Jan 2013
Agaimy Abbas, Otto Claudia, Braun Alexander, Geddert Helene, Schaefer Inga-Marie, Haller Florian
Abstract excerpt
AIMS: Genotyping is a prerequisite for tyrosine kinase inhibitor therapy in high risk and malignant GIST. About 10% of GISTs are wild-type for KIT but carry PDGFRA mutations. Applying the traditional approach, mutation analysis of these cases is associated with higher costs if all hotspots regions in KIT (exon 9, 11, 13, 17) are performed at first. Our aim was to evaluate the predictive value of a combined...
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