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Article

Uveal Melanoma and the Lynch Syndrome Tumor Spectrum.

JAMA ophthalmology - 1 Aug 2025

Le Ven Anaïs, Villy Marie-Charlotte, Silveira André Bortolini, Houy Alexandre, Masliah-Planchon Julien, Warcoin Mathilde, Le Mentec Marine, Simaga Fatoumata, De Pauw Antoine, Buecher Bruno, Gauthier-Villars Marion, Verrier Thibault, Merchadou Kevin, Renault Victor, Vincent-Salomon Anne, Sauge Juliette, El Zein Sophie, Dubois d'Enghien Catherine, Piperno-Neumann Sophie, Matet Alexandre, Malaise Denis, Cassoux Nathalie, Lumbroso-Le Rouic Livia, Stoppa-Lyonnet Dominique, Stern Marc-Henri, Rodrigues Manuel, Golmard Lisa, Colas Chrystelle

Abstract excerpt

Importance: To date, no environmental factors and few therapeutic options are known for uveal melanoma (UM), the most common malignant intraocular primary tumor in adults. Identification of new predisposition factors could lead to better monitoring and possibly improved treatments of patients with UM. Objective: To identify new genetic alterations predisposing for UM. Design, Setting, and Participants: This was a...

Topics

Humans
Melanoma
Male
Female
Middle Aged
Uveal Neoplasms
Prospective Studies
Uveal Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Colorectal Neoplasms, Hereditary Nonpolyposis

Germ-Line Mutation

Aged

Adult

Genetic Predisposition to Disease

Genetic Testing

Source

Open in PubMed Open full text

Identifiers

PMID: 40531527
DOI: 10.1001/jamaophthalmol.2025.1779
PMCID: PMC12177725

Genes

MLH1
ID1
ID2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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