Article
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours.
Nature communications - 15 May 2020
Johansson Peter A, Brooks Kelly, Newell Felicity, Palmer Jane M, Wilmott James S, Pritchard Antonia L, Broit Natasa, Wood Scott, Carlino Matteo S, Leonard Conrad, Koufariotis Lambros T, Nathan Vaishnavi, Beasley Aaron B, Howlie Madeleine, Dawson Rebecca, Rizos Helen, Schmidt Chris W, Long Georgina V, Hamilton Hayley, Kiilgaard Jens F, Isaacs Timothy, Gray Elin S, Rolfe Olivia J, Park John J, Stark Andrew, Mann Graham J, Scolyer Richard A, Pearson John V, van Baren Nicolas, Waddell Nicola, Wadt Karin W, McGrath Lindsay A, Warrier Sunil K, Glasson William, Hayward Nicholas K
Abstract excerpt
Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress to metastatic disease. Therapeutic options for metastatic UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) of 103 UM from all sites of the uveal tract (choroid, ciliary body, iris). While most UM have...
Topics
- Cell Line, Tumor
- Chromosome Aberrations
- Computational Biology
- DNA Mutational Analysis
- Disease Progression
- Disease-Free Survival