Article
Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nature communications - 9 Jun 2020
Wu Daichao, Gallagher D Travis, Gowthaman Ragul, Pierce Brian G, Mariuzza Roy A
Abstract excerpt
Adoptive cell therapy (ACT) with tumor-specific T cells can mediate cancer regression. The main target of tumor-specific T cells are neoantigens arising from mutations in self-proteins. Although the majority of cancer neoantigens are unique to each patient, and therefore not broadly useful for ACT, some are shared. We studied oligoclonal T-cell receptors (TCRs) that recognize a shared neoepitope arising from a...
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