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Article

An emergent biofilm program from inactivation of Candida albicans master regulators Efg1 and Ndt80.

PLoS pathogens - 1 Jul 2026

Do Eunsoo, Zarnowski Robert, Andes David R, Mitchell Aaron P

Abstract excerpt

Biofilm formation by the fungus Candida albicans is a central virulence trait that enables colonization of implanted medical devices and mucosal surfaces. Biofilm formation reflects a complex regulatory network, and depends upon multiple master regulators that include transcription factors Efg1 and Ndt80. It is well established that efg1Δ/Δ and ndt80Δ/Δ single gene mutants are defective in biofilm formation. We...

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Identifiers

PMID: 42475389
DOI: 10.1371/journal.ppat.1014469
PMCID: PMC13399525

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