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Article

Strain-limited biofilm regulation through the Brg1-Rme1 circuit in Candida albicans.

mSphere - 28 Jan 2025

Kim Min-Ju, Mitchell Aaron P

Abstract excerpt

Prominent virulence traits of Candida albicans include its ability to produce filamentous hyphal cells and grow as a biofilm. These traits are under control of numerous transcription factors (TFs), including Brg1 and Rme1. In the reference strain SC5314, a brg1Δ/Δ mutant has reduced levels of biofilm/filament production; a brg1Δ/Δ rme1Δ/Δ double mutant has wild-type levels of biofilm/filament production. Here, we...

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Identifiers

PMID: 39745385
DOI: 10.1128/msphere.00980-24
PMCID: PMC11774020

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