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Article

Hypoxic Adaptation by Efg1 Regulates Biofilm Formation by <i>Candida albicans</i>

4 Apr 2009

Abstract excerpt

Hypoxia is encountered frequently by Candida albicans during systemic infection of the human host. We tested if hypoxia allows biofilm formation by C. albicans, which is a major cause of perseverance and antifungal resistance in C. albicans infections. Using an in vitro biofilm system, we unexpectedly discovered that several positive regulators of biofilm formation during normoxia, including Tec1, Ace2, Czf1,...

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PMID: 19346360
DOI: 10.1128/aem.00098-09

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