Weakened macrophage antibacterial capacity in myelodysplastic syndrome.

Abstract excerpt

Patients with myelodysplastic syndrome (MDS) are immunocompromised and are therefore susceptible to fatal infection. While neutropenia and neutrophil dysfunction account for much of this immunodeficiency, other immune cells likely also contribute. In contrast to the extensive study of neutrophils in MDS, there has been very little investigation of macrophage host defense function in MDS. In the current study, we...

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