Allostatic load elevates the risk and adverse prognosis of immune-mediated inflammatory diseases: modulatory effects of lifestyle interventions and genetic susceptibility.

Abstract excerpt

BACKGROUND: Allostatic load (AL)-the cumulative biological cost of lifelong stress-can disrupt immune homeostasis via hypothalamic-pituitary-adrenal-axis dysregulation and persistent sympathetic activation. Immune-mediated inflammatory diseases (IMIDs) are organ-specific chronic inflammatory disorders imposing a major public-health burden, yet their causal link with AL remains unclear. METHODS: In this...

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