Bidirectional Mendelian randomization of childhood maltreatment and sleep-related phenotypes.

Abstract excerpt

Background: Childhood maltreatment (CM) is associated with sleep disturbance, but observational findings may be affected by confounding, shared familial liability, and reverse-direction explanations. We conducted bidirectional two-sample Mendelian randomization (MR) to examine genetic evidence linking composite CM liability with six sleep-related phenotypes.Methods: Genetic instruments for CM were obtained from a...

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• Child
• Child Abuse
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Phenotype