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Article

Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study

1 Feb 2025

Abstract excerpt

Background: Observational studies have demonstrated a strong association between sleep disturbances and frailty. However, the causality remains inconclusive. We aimed to investigate the bidirectional causal relationships between frailty measures and sleep disturbances employing a two-sample Mendelian randomization (MR) analysis. Methods: Two-sample MR analyses were performed based on large-scale genome-wide...

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PMID: 39936043
DOI: 10.2147/nss.s497173

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