Article
The hidden costs of dietary restriction: Implications for its evolutionary and mechanistic origins.
Science advances - 1 Feb 2020
McCracken Andrew W, Adams Gracie, Hartshorne Laura, Tatar Marc, Simons Mirre J P
Abstract excerpt
Dietary restriction (DR) extends life span across taxa. Despite considerable research, universal mechanisms of DR have not been identified, limiting its translational potential. Guided by the conviction that DR evolved as an adaptive, pro-longevity physiological response to food scarcity, biomedical science has interpreted DR as an activator of pro-longevity molecular pathways. Current evolutionary theory...
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