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Pleiotropic effects of direct oral anticoagulants on the coagulation-inflammation-endothelium axis: A phenotype-stratified narrative review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Sept 2026

Wołowiec Łukasz, Wesołowska Weronika, Skibicka Katarzyna, Jaśniak Albert, Banach Joanna, Osiak Joanna, Wołowiec Anna, Skibicki Tomasz, Grześk Grzegorz

Abstract excerpt

AIMS: Direct oral anticoagulants (DOACs) - dabigatran (a thrombin inhibitor) and rivaroxaban, apixaban, and edoxaban (factor Xa [FXa] inhibitors) - modify oxidative stress, endothelial inflammation, and barrier integrity beyond anticoagulation. We ask whether this reflects distinct pharmacology or silencing of proteases at protease-activated receptors (PARs), and propose a three-condition framework for when it...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42462434
DOI: 10.1016/j.biopha.2026.119768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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